The first trailer has arrived for the R-rated road trip comedy “The Layover,” William H. Macy’s second directorial effort which sees Kate Upton and Alexandra Daddario play a pair of lifelong best friends who decide to avoid their problems by taking a vacation.

They soon find that their plane has been rerouted due to a hurricane warning, and get into a battle for the same guy (Matt Barr) during an extended layover in St. Louis. Matt Jones, Rob Corddry, Kal Penn and Molly Shannon co-star and the film opens September 1st.

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